The effects of transient cerebral ischemic reperfusion and flunarizine on the expression of plasminogen activator inhibitor-1 protein in brain tissue of gerbils
- VernacularTitle:沙鼠脑缺血性再灌注及西比灵干预对PAI-1表达变化的影响
- Author:
Wensheng ZHOU
;
Zhiping HU
;
Yan HONG
- Publication Type:Journal Article
- Keywords:
Reperfusion;
Brain ischemia;
Flunarizine;
Plasminogen activator inhibitor 1
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of transient cerebral ischemic reperfusion(IR) and flunarizine on the expression of plasminogen activator inhibitor-1(PAI-1) protein in brain tissue of gerbils.Methods A cerebral transient ischemic-reperfusion model in gerbils was established by clamping both common carotid.The gerbils were fed with flunarizine before experiment in flunarizine treatment group.The expression of PAI-1 protein in brain tissue was detected by immunohistochemistry technique at the 1,3 and 7 days after IR.Results There was slight expression of PAI-1 protein in the brain tissue of gerbils in the normal control group and sham operation group.Compared with normal control group,the expression of PAI-1 protein in neurons and gliacytes of ischemic gerbils was evidently increased at the 1,3 and 7 days in the cerebral ischemia group(all P
