Clinical significance of the changes of monocyte chemoattractant protein-1 in patients with pregnancy induced hypertension
- VernacularTitle:妊娠高血压综合征患者单核细胞趋化蛋白-1变化的意义
- Author:
Zifen WANG
;
Hongyan WANG
;
Haixiang SONG
- Publication Type:Journal Article
- Keywords:
Hypertension,pregnancy-induced;
Monocyte chemoattractant protein-1
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of changes of monocyte chemoattractant protein-1(MCP-1) in patients with pregnancy induced hypertension(PIH).Methods The MCP-1 levels of urine and blood were measured by enzyme linked immunosorbent assay(ELISA) in 96 patients with PIH and 49 normal pregnant women.Results The MCP-1 levels in blood and urine in patients with PIH were significantly higher than those in normal pregnant women,and were associated with the severity of the disease.The urine MCP-1 level was positively correlated with the levels of ?_2-microglobulin(?_2-MG),N-acety1-?-D-glucosaminidase(NAG),interleukin-6(IL-6) and retinal-binding protein(RBP),and was negatively correlated with creatinine clearance rate(Ccr).Conclusion The detection of MCP-1 is useful for examining the severity of PIH and the degree of renal injury.
