Diagnostic value of multiple tumor marker protein biochip detective system for patients with lung cancer
- VernacularTitle:多肿瘤标志物蛋白芯片检测方法对肺癌的诊断研究
- Author:
Shuwen DONG
;
Yan DING
;
Xiaojian QIU
;
Fei GAO
;
Xiuping WEI
;
Binwen DANG
;
Jie ZHANG
- Publication Type:Journal Article
- Keywords:
Tumor markers;
Protein biochip;
Lung cancer
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate diagnostic values of multi-tumor markers protein biochip detective system for lung cancer. Methods Patients with lung cancer group(78 cases),benign pulmonary diseases group (118 cases) and control group (68 cases) were enrolled.Twelve tumor markers in serum (AFP,CEA,NSE,CA125,CA153,CA242,CA199,PSA,f-PSA,FER,?-HCG and HGH) were measured by the multi-tumor markers protein biochip detective system. Result The serum levels of CEA,CA125,Fer and CA242 in the lung cancer group were much higher than those of the other two groups.There were no significant differences of serum levels and positive rates of other tumor markers among three groups.The sensitivity of CEA,CA125,Fer and CA242 was 41.0%,35.9%,26.9% and 17.9% respectively,the specificity 89.8%,86.0%,86.6% and 95.7% respectively。 Conclusions The multi-tumor markers protein biochip detective system has diagnostic values in lung cancer.When more than three markers are positive simultaneously,the sensitivity was 24.4%,and the specificity was 96.8%.The result could help to detect the character of tumor.
