Role of islet B cell dysfunction in the pathogenesis of type 2 diabetes mellitus
- VernacularTitle:2型糖尿病家系成员胰岛B细胞功能状态的研究
- Author:
Zongming HE
;
Yanhu DONG
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Islet dysfunction;
First-degree relatives;
Islet B cell
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of islet B cell dysfunction in the pathogenesis of type 2 diabetes mellitus. Methods FBG and fasting plasma insulin of 49 healthy subjects and 125 first-degree relatives of type 2 diabetes mellitus were determined. HOMA model was used to calculate HOMAIR as an index of insulin resistance and HOMAB as an index of B cell function of pancreatic islet.The insulin sensitivity index(ISI) and early-stage secretion index of islet ?cell(△I_ 30 /△G_ 30 )were calculated. Results The HOMAB and △I_ 30 /△G_ 30 of the group of normal first-degree relatives were higher (P
