Intervention Effect of Puerarin on Expressions of HSP70 and Fas Proteinum in Rats with Acute Cerebral Ischemia Injury
- VernacularTitle:葛根素对急性脑缺血模型大鼠脑细胞损伤后HSP70及Fas蛋白表达的干预作用研究
- Author:
Hongping PAN
;
Jiazhen YANG
;
Xianglan MO
;
Luli LI
;
Zhenlu HUANG
;
Jing YE
;
Jin HUANG
- Publication Type:Journal Article
- Keywords:
Puerarin;
Acute cerebral ischemia injury;
HSP70;
Fas proteinum
- From:
China Pharmacy
1991;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the intervention mechanism of puerarin on expressions of HSP70 and Fas proteinum in rats with acute cerebral ischemia injury.METHODS:12 rats with acute cerebral ischemia injury were randomly divided into ischemia control group(saline) and puerarin treated control group,with 6 in each group,each rat under took own control by ischemia side(exp.group) and non-ischemia side(control group);And rats with acute cerebral ischemia injury were randomly divided into control group (saline,ischemia side),puerarin treated control group and normal group (non-ischemia side),with 6 in each group.And then the expressions of HSP70 and Fas proteinum is determined by HE staining and immunochistochemistry SP.RESULTS: The expression of HSP70 was negative or weakly positive in ischemia control group and puerarin treated control group, while that in ischemia experiment group and puerarin treated experiment group was significantly increased(P0.05);The numbers of dead cells in control group and puerarin group were found to be significantly larger than that in normal group(P
