Effect of Eating on Pharmacokinetics of Ethanesulfonic Acid Levofloxacin Tablets
- VernacularTitle:进食对口服甲磺酸左氧氟沙星片药动学的影响
- Author:
Xiuli ZHAO
;
Shumin WANG
;
Jiajing LI
;
Feng WU
;
Yanli CUI
;
Hui ZHOU
- Publication Type:Journal Article
- Keywords:
Ethanesulfonic acid levofloxacin;
HPLC;
Pharmacokinetics
- From:
China Pharmacy
1991;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To investigate the effect of eating on pharmacokinetics of ethanesulfonic acid levofloxacin tablets.METHODS: The blood concentration of 10 healthy male subjects were determined by HPLC after receiving single oral dose of 200mg ethanesulfonic acid levofloxacin both before and after eating by randomized crossover way.The data processing was conducted with 3p97 software so as to figure out the pharmacokinetic parameters.RESULTS: The plasma concentration-time curves of the subjects after administration of drugs were in conformity with two-compartment model.The respective main pharmacokinetic parameters of the eating group and the empty stomach group were as follows: Cmax were (1.91?0.36)mg/L and(2.16?0.69) mg/L; AUC0～t were (14.14?2.32)(mg?h)/L and(14.40?3.11)(mg?h)/L; t1/2? were(6.59?1.66)h and(6.94?0.81 )h.CONCLUSION: Neither eating nor empty stomach has effect on the pharmacokinetics of ethanesulfonic acid levofloxacin tablets.
