Study on electroacupuncture at Zusanli points(足三里穴) against hemorrhagic shock of rats through activating cholinergic antiinflammatory pathway
- VernacularTitle:电针足三里激活胆碱能抗炎通路抗大鼠失血性休克的研究
- Publication Type:Journal Article
- Keywords: electroacupuncture; Zusanli points; hemorrhagic shock; cholinergic antiinflammatory pathway
- From: Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2006;0(01):-
- CountryChina
- Language:Chinese
- Abstract: Objective: To investigate the therapeutic effect and mechanism of electroacupuncture(EA) at Zusanli points(足三里穴) on the changes of mean arterial pressure(MAP),arterial lactate levels and(survival) indexes in rats with hemorrhagic shock(HS).Methods: One hundred SD rats were randomly divided into ten groups(n=10): sham shock group,HS group,nonacupoint group,Zusanli point group,bilateral cervical vagotomy group,vagotomy and EA group,muscarinic antagonist group,nicotinic antagonist group,(?bungarotoxin)(?BGT) group and(tetrahydroaminoacridine)(THA) group.Zusanli points were(electroacupunctured) with constant voltage(24 V,3 Hz) for 30 minutes immediately after the shock model was established.Before the stimulation the carotid artery was(intubated) for continuously mornitoring MAP.The levels of serum lactate in the femoral artery were detected at 0 and 43 minutes.Another 40 rats were(randomly)(divided) into sham shock group,HS group,nonacupoint group and Zusanli point group.Survival time and(survival) rate were observed in the four groups.Results: MAP was lower continuously,and the(survival) time and(survival) rate were lower in HS group,the levels of lactate was higher at 43 minutes(compared) with that of 0 minute(all P0.05).After EA at Zusanli point,MAP,survival time and(survival) rate gradually increased but lactate obviously(decreased) at 43 minutes(compare) with that at 0 minute(all P0.05).Atropine injected intravenously(before) EA at Zusanli point could produce the protective effects as same as that of Zusanli group,but after injecting hexamethonium bromide or ?BGT,the protective effects disappeared.Conclusion: The results suggest that EA Zusanli points produce a protective effect on HS of rats by the way of activating cholinergic antiinflammatory pathway.