The effects of arsenic trioxide on the cell cycle and microfilament cytoskeleton in human nasopharyngeal carcinoma cell line
- VernacularTitle:三氧化二砷对鼻咽癌细胞周期和细胞骨架微丝的影响
- Author:
Zhizhong SHEN
;
Zhixiong LIN
;
Manhong LI
;
Juelong LIN
;
Dehui SONG
;
Huige WANG
- Publication Type:Journal Article
- Keywords:
Arsenic Compounds;
Nasopharyngeal Neoplasms;
Apoptosis;
Cell Cycle;
Microfilaments
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the effects of arsenic trioxide (As2O3) on the cell cycle and microfilament cytoskeleton in human nasopharyngeal carcinoma cell line(CNE1),as well as possible mechanisms. METHODS The variation of cell cycle and microfilament cytoskeleton in CNE1 were observed using the flow cytometry (FCM),the laser scanning confocal microscopy(LSCM)and technology of fluorescence.RESULTS FCM showed that the proportion of G1 phase cells significantly increased in cells exposed to 2 and 4?mol/L As2O3(P
