Relationship between expressions of HSP70 and HPV16E7 protein in human laryngeal squamous cell carcinoma
- VernacularTitle:喉癌组织中热休克蛋白和人乳头状瘤病毒的相关性
- Author:
Xinjiang YING
;
Shuwei ZHAO
;
Jie QIU
;
Qing YE
;
Aihua SUN
- Publication Type:Journal Article
- Keywords:
Laryngeal Neoplasms;
Heat-Shock Proteins 70;
Papilloma- virus,Human
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the expressions of heat shock protein 70 and human papillomavirus16E7 protein in human laryngeal squamous cell carcinoma, and their relationship in the genesis of human laryngeal squamous cell carcinoma. METHODS The expressions of HSP70 and HPV16E7 protein were detected by the immunohistochemical method in 78 specimens with laryngeal squamous cell carcinoma, 24 specimens with vocal cord polyps and 10 specimens of normal laryngeal tissues. RESULTS In human laryngeal squamous cell carcinoma, vocal cord polyps and normal laryngeal tissues, the positive expression rates of HSP70 were 69.2 % , 8.3 % and 0 % respectively, with those of HPV16E7 protein being 43.6 % 4.2% and 0 % respectively. There was a significant difference of the expression rate of HSP70 or HPV16E7 protein between the laryngeal squamous cell carcinoma and the vocal cord polyps(P
