Investigation of GR-? m RNA quantitative expression in nasal polyps
- VernacularTitle:糖皮质激素受体-?mRNA在鼻息肉组织中的定量表达
- Author:
Peng LI
;
Yuan LI
;
Xian LIU
;
Jin YE
;
Zhenlin WANG
;
Qintai YANG
;
Bin HU
- Publication Type:Journal Article
- Keywords:
Nasal Polyps;
Glucocorticoids;
Receptors,Glucocorticoid;
Fluorescent Quantitative PCR(FQ-RT-PCR);
Administration,Intranasal
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To detect the expression of the Glucocorticoid receptor-?(GR-?)mRNA in nasal polyp and normal nasal mucosa and investigate the route of nasal drug administration in patients of nasal polyp. METHODS The expression of GR-?mRNA in 101 samples of nasal polyps and 31samples of normal nasal mucosa was examined by using Fluorescent quantitative PCR .RESULTS The level of GR-?mRNA in normal nasal mucosa(135.4? 5.25)?104 copy /?g were significantly higher than that in nasal polyps(23.5?12.1)?104 copy/?g . CONCLUSION Because of the low expression of GR-?mRNA in nasal polyps,the route of nasal drug administration in patients with nasal polyps may be in the part of normal mucosa,not in the mucosa of nasal polyps of the nasal cavity.
