Effect of batroxobin on the blood-retinal barrier and vascular endothelial growth factors in diabetes rats
- VernacularTitle:巴曲酶对糖尿病大鼠血视网膜屏障和视网膜血管内皮生长因子表达的影响
- Author:
Yan LUO
;
Lingling XU
;
Chengfen ZHANG
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Diabetes;
Blood-retinal barrier;
Endothelium,vascular;
Endothelial growth factors
- From:
Chinese Journal of Ocular Fundus Diseases
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of batroxobin on the blood-retinal barrier (BRB) and vascular endothelial growth factors (VEGF) in diabetic rats. Methods Sixty Sprague-Dawley rats were used to establish diabetic models by intraperitoneal injecting with streptozotocin (60 mg/kg), and were divided into 3 groups: diabetic group (n=20), batroxobin (40 mg/kg) group (n=20) and batroxobin (20 mg/kg) group (n=20). Twenty-five else rats were in control group. All of the rats were executed 7 days later. The function of BRB was observed by Evans blue method. Results concentration of VEGF protein was detected by enzyme-linked immunoabsorbert assay (ELISA). The results of each group were compared. Results The content of BRB leaked into retina was obvious lower in the control group than which in the other 3 diabetic groups(P0.05). The content of Evans blue was lower in the 2 diabetic groups with different dosage of batroxobin than which in the control group (P
