The relationship between HBV replicative markers and hepatocarcinogenesis
- VernacularTitle:乙肝病毒活跃复制与肝细胞癌发生的相关性研究
- Author:
Feng ZHANG
;
Yongfu SHAO
;
Yang XU
;
Jidong GAO
;
Guoting LIU
;
Libin XU
;
Zongtang SUN
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Hepatitis B virus;
Hepatitis B e antigen;
cccDNA
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the association strength of the prevalence of HBeAg, cccDNA with the occurrence of HBV related hepatocellular carcinoma (HCC) in high risk male cohort in Qidong area in China. Methods A cohort of 377 middle aged HBV infected men in Qidong was followed from 1989 for 13. 25 years. HCC cases were registered. A matched case-controlled study was conducted on 32 pairs of inherent HCC cases with non-HCC controls. Serum HBeAg was measured by ELISA. cccDNA was detected by semi-nested PCR and verified by DNA sequencing. Standard statistical comparison between the prevalence of each HBV marker in HCC versus control group provided the odds ratio and P-value was used to evaluate its association strength with HCC occurrence. Results Serum HBeAg prevalence was 53. 1% (17/32) in HCC group versus 15. 6% (5/32) in controls, odds ratio (OR) =6. 12, P
