Effects of low-dose recombinant human growth hormone on severity of illness in patients with systemic sepsis
- VernacularTitle:小剂量生长激素对腹腔源性脓毒症患者的影响
- Author:
Xi ZHU
;
Min YI
;
Qinggang GE
;
Gaiqi YAO
;
Haixia WANG
;
Hongliang LI
- Publication Type:Journal Article
- Keywords:
Somatropin;
Sepsis
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of growth hormone on illness severity and prognosis of septic patients. Methods Thirty septic shock patients were randomized into control group (10 cases) and growth hormone treatment group (20 cases) , to receive 8 U recombinant human growth hormone every day for 7 consecutive days, control group received NS. Serum concentration of procalcitonin ( PCT) , C-reactive protein ( CRP) , tumor necrosis factor-? ( TNF-?) and interleukin-6 ( IL-6 ) were measured on the 1st,4th,and 7th day. The severity of illness was assessed daily with the Acute Physiology and Chronic Health Evaluation-Ⅱ (APACHE-Ⅱ ) scoring system and the Elebute & Stoner's Sepsis scoring system. The efficacy also were evaluated on day 15 postoperation. Results The serum concentration of PCT, CRP, TNF-?, IL-6 decreased gradurally in both group after study starting. PCT, TNF-? and IL-6 were significantly different on the 7th day in both group (P
