Interphase FISH of amniocytes in the third trimester
- VernacularTitle:孕晚期羊水细胞的荧光原位杂交
- Author:
Zeshan YOU
;
Jia HUANG
;
Jiansheng CHEN
- Publication Type:Journal Article
- Keywords:
Amniocentesis;
Pregnancy trimester, third;
In situ hybridization, fluorescence
- From:
Chinese Journal of Perinatal Medicine
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the interphase FISH of cells from aminotic fluid in the third trimester prospectively. Methods Amniotic fluid (5ml) was obtained in 32 pregnant women in the third trimester who underwent cordocentesis for karyotyping. FISH was performed on uncultured am niocytes and the results were compared with karyotypes. Results Abnormal aneuploid were identified in 6 cases among the 32 women. The FISH results were consistent with the karyotypes. Conclusions Interphase FISH in third-trimester amniocentesis can provide an accurate clinical diagnosis on common aneupoidies.
