Protective Effect of Diphenyl Ethylene Glycoside on Hippocampal Neuron Cells Ischemic Injury Model Rats
- VernacularTitle:二苯乙烯苷对海马神经元细胞缺血性损伤模型大鼠的保护作用研究
- Author:
Yali LI
;
Ling ZHAO
;
Lin LI
- Publication Type:Journal Article
- Keywords:
Diphenyl ethylene glycoside;
Hippocampal nerve cell;
Ischemic injury;
Sodium dithionite;
Protection effect
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the protective effects of diphenyl ethylene glycoside(TSG)on hippocampal neuron cells ischemic injury model rats.METHODS:Hippocampal nerve cells ischemic injury rats’model was established with sodium dithionite,antagonism of TSG on ischemic cerebral injury was determined by methyl thiazolyl tetrazolium(MTT)microcol-orimetry and lactate dehydrogenase(LDH)efflux assay.RESULTS:Pseudo-ischemic cerebral injury could cause significant injury to neurons with elevated cell death rate,significantly decreased MTT value and increased LDH efflux rate.The appli-cation of TSG could lead in significantly decreased LDH efflux rate,elevated MTT value and reduced cell death rate.CON-CLUSION:TSG has a significant protective effect on nerve cells ischemic injury model rats.
