Comparison among Several Preparation Methods for Pseudo-ternary Phase Diagrams of Pharmaceutical Microemulsions
- VernacularTitle:药用微乳伪三元相图的几种制备方法比较研究
- Author:
Guoliang PAN
;
Xiaobin JIA
- Publication Type:Journal Article
- Keywords:
Pseudo-ternary phase diagram;
Microemulsion;
Emulsifier;
Assistant emulsifier;
Preparation method
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate and compare the current preparation methods for pseudo-ternary phase diagrams of pharmaceutical microemulsions.METHODS:Pseudo-ternary phase diagrams were prepared by using Tween-80,OP and lecithin as emulsifiers respectively,alcohol as assistant emulsifiers,isopropyl myristate or aethylis oleas as the oil phase,the difference in phase diagrams obtained with different preparation methods was compared with regard to the accuracy and au-thenticity of valid point.RESULTS:To O/W surfactant,difference in the area of phase diagrams was small,but the dis-tinction of accuracy and authenticity of valid point was great.To W/O surfactant,difference in the area of phase diagrams was great.CONCLUSION:It is recommended to select the preparation method according to the characteristics of the constituents and the types of microemulsions in order to establish accurate and dependable phase diagram,the end point of titration should be judged comprehensively.
