Preparation and Quality Control of Recombinant Interferon ?1b Chitosan Plastics
- VernacularTitle:重组干扰素?1b壳聚糖涂膜剂的制备及质量控制
- Author:
Yong CHEN
- Publication Type:Journal Article
- Keywords:
Recombinant interferon ?1b;
Chitosan;
Plastics;
Preparation;
Quality control
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare recombinant interferon(INF)?1b chitosan plastics and to establish a way for its quality control.METHODS:The plastics was prepared with chitosan as the main excipients,the content of INF?1b was de-termined by di-quinoline methanoic acid kit,the stability of the plastics was determined and its skin irritation test was con-ducted.RESULTS:The linear range for recombinant INF?1b in the prepared paint was1～11mg/L(r=0.9999)with methodological recovery rate at101.04%,RSD=1.05%(n=5).CONCLUSION:The recombinant INF?1b chitosan plastics is simple in preparation,accurate in assaying,stable in quality yet the skin irritation induced by which was failed to be noted.
