Protective effect of Ginkgo Biloba leaves extracta preconditioning on liver graft in rat liver transplantation
- VernacularTitle:银杏叶提取物预处理对大鼠移植肝的保护作用
- Author:
Zongjiang XIA
;
Qifa YE
;
Yingzi MING
;
Jiebin ZHOU
;
Bing NIU
- Publication Type:Journal Article
- Keywords:
Liver Transplantation;
Reperfusion Injury/prev;
Extracta of Ginkgo Biloba Leaves
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of Ginkgo Biloba leaves(EGb) preconditioning on liver graft in rat liver transplantation.Methods Male Sprague-Dawley rats were used as donors and(recipients) of orthotopic liver transplantation(OLT).The rats were randomly divided into EGb group,normal saline(NS) control group and sham operation(SO) group.The animals were killed at 2h,6h,24h after graft reperfusion.Plasma samples were collected for ALT and AST test.Liver tissues were collected to detect the expression of TNF-?mRNA and Bcl-2mRNA by RT-PCR.Also,liver tissues were used to detect rat(liver) histological change and apoptosis by TUNEL.Results The serum levels of ALT in EGb group were(significantly) lower than the NS group(P
