Effect of potassium channels on acute hypoxic pulmonary vasoconstriction in COPD and chronic hypoxic patients
- VernacularTitle:COPD合并慢性缺氧患者肺血管对急性缺氧反应变化中肺动脉平滑肌细胞钾通道的作用
- Author:
Tao WANG
;
Zhenxiang ZHANG
;
Yongjian XU
- Publication Type:Journal Article
- Keywords:
Pulmonary disease, chronic obstructive;
Pulmonary artery;
Potassium channels, voltage-gated;
Potassium channels, calcium-activated;
Anoxia
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The aim of this study is to investigate the possible role of potassium channel in hypoxic pulmonary vasoconstriction (HPV). METHODS: Fresh human lung tissues were obtained from the Division of Chest Surgery to establish a human model of HPV in vitro. Three groups, control group, COPD group and COPD plus chronic hypoxia group were divided. Human isolated pulmonary artery rings and specific blocking agent corresponding to K_V, K_ Ca, K_ ATP were used to investigate the possible role of the potassium channel in HPV. RESULTS: (1) In acute hypoxia, the vascular ring tension in three groups all increased (P
