Role of heme oxygenase-endogenous carbon monoxide in the regulation of cardiac function during lipopolysaccharide shock in rats
- VernacularTitle:血红素氧合酶-内源性一氧化碳系统对脂多糖性休克大鼠心脏的影响
- Author:
Jianbo YU
;
Shanglong YAO
;
Shiying YUAN
- Publication Type:Journal Article
- Keywords:
Shock;
Heme oxygenase;
Heart;
Carbon monoxide
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To clarify the role of heme oxygenase-endogenous carbon monoxide (HO-CO) in the regulation of cardiac function during lipopolysaccharide (LPS) shock in rats. METHODS: Forty healthy Sprague-Dawley rats were divided into four groups randomly (n=10 in each group): control group (group C), ZnPP-IX group (group Z), LPS shock group (group S) and LPS shock+ZnPP-IX (group LZ). The LVSP and ?dp/dt_ max were monitored before and after administration of ZnPP-IX or sodium bicarbonate vehicle intraperitoneally in four groups. LDH, CK and COHb of plasma, and HO-1 mRNA, HO-2 mRNA, HO-1 protein and HO-2 protein from left ventricle tissue were measured 6 h after LPS (or 0.9% saline vehicle) injection in four groups. RESULTS: ① The LVSP and ?dp/dt_ max in group LZ were obviously lower than that in group S, respectively (P0.05). CONCLUSION: The upregulation of HO-1 protein followed by increase in CO may contribute to protection of cardiac function during septic shock in rats.
