Change of estrogen receptor in hippocampus, hypothalamus and pituitary of female rats exposed to psychological stress
- VernacularTitle:心理应激雌性大鼠海马-下丘脑-垂体雌激素受体的变化
- Author:
Jiangwei KE
;
Jianhong WANG
;
Rong DUAN
- Publication Type:Journal Article
- Keywords:
Stress;
Hippocampus-hypothalamus-pituitary;
Receptors, etrogen;
Immunohistochemistry
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the change of estrogen receptor (ER) in hippocampus, hypothalamus and pituitary of female rats exposed to psychological stress, and to illuminate the mechanism of dysfunction on ovarian reproductive endocrine function. METHODS: Sound, light and electricity were combined into a psychological stressful stimulus to induce female rat dysfunction on ovarian reproductive endocrine function. Immunohistochemical technique and image analysis were used to assess the expression levels of ER in hippocampus, hypothalamus and pituitary. RESULTS: When exposed to compound stressful stimulus of sound, light and electricity for 20 days in female rats, the expression levels of ER in hippocampus, hypothalamus and pituitary dropped. CONCLUSION: The decrease in estrogen receptor expression in hippocampus, hypothalamus and pituitary of female rats exposed to psychological stress may be one of the mechanisms of ovarian reproductive endocrine dysfunction.
