Effects of lidocain and gentamycin on inflammation reaction and wound infection of explosive wound in limb arthrosis after seawater immersion[STBZ]
- VernacularTitle:利多卡因、庆大霉素对海水浸泡的肢体关节爆炸伤炎症反应及创面感染的影响
- Author:
Xuefei ZHANG
;
Huiqiang SHI
;
Daping XIAO
;
Xinzhong LI
;
Ping XU
;
Bujing XU
- Publication Type:Journal Article
- Keywords:
Lidocaine;
Gentamicins;
Explosion wound;
Seawater immersion
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of lidocain and gentamycin on inflammation reaction and wound infection of explosive wound in limb arthrosis after seawater immersion. METHODS: The explosive wound were made in 48 New Zealand white rabbits. All rabbits were randomly divided into 4 groups: lidocain, gentamycin and glutin sponge bound up and immersed in seawater 1 h group (LGGS group, n=12); bactroban and glutin sponge bound up and immersed in seawater 1 h group (BGS group, n=12); 12 layers common gauze bound up and immersed in seawater 1 h group (GS group, n=12) and 12 layers common gauze bound up 1 h group (G group, n=12). The changes of blood WBC, CRP, IL-1, IL-6, TNF-?, MDA and SOD in each group were tested. The bacterial culture was performed in each group after explosion 1 h, 3 d, 7 d and 1 month. RESULTS: Compared with pre-experiment, the WBC was decreased, the IL-6 and TNF-? values were increased significantly (P0.05), but the other groups did (P
