Role of FPRL1 in the chemotaxis of polymorphonuclear leukocytes stimulated by LPS and its regulation by polydatin
- VernacularTitle:甲酰化肽样受体介导脂多糖诱导的白细胞趋化反应及虎杖甙的调节作用研究
- Author:
Haixiao HUANG
;
Qing ZHAO
;
Chunhua JIN
- Publication Type:Journal Article
- Keywords:
Polydatin;
Chemotaxis;
Lipopolysaccharides;
Neutrophils
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the chemotaxis mechanisms of polymerphonuclear leukocytes (PMNs) under the stimulation of LPS and its regulation by polydatin (PD). METHODS: Chemotactic chamber assay was used to investigate the regulatory role of formyl peptide receptor like-1 (FPRL1) in the chemotaxis of PMNs in response to LPS and PD. RESULTS: LPS increased the secretion of PMN chemotactic factor and up-regulated the function of formyl peptide receptor like-1. PD did not obviously affect the chemotactic factor secretion in normal PMN and the function of formyl peptide receptor like-1, but it significantly reduced the rise of chemotactic factor excretion in PMNs caused by LPS stimulation and PMNs transfected with formyl peptide receptor like-1. CONCLUSION: FPRL1 may mediate LPS-induced PMN chemotaxis, and PD regulates PMN chemotaxis by down-regulating the secretion of chemokine and the function of FPRL1 and may play a crucial role in the treatment of inflammation.
