Expression of CD2AP and F-actin in rats with puromycin aminonucleoside nephrosis
- VernacularTitle:CD2AP、F-actin在肾病大鼠中的表达及意义
- Author:
Fei ZHAO
;
Songming HUANG
;
Aihua ZHANG
;
Li FEI
;
Mei GUO
;
Ronghua CHEN
- Publication Type:Journal Article
- Keywords:
CD2-associated protein;
Nephrosis;
Cytoskeleton;
Microfilaments
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of CD2AP and F-actin in the pathogenesis of puromycin aminonucleoside nephrosis in rats. METHODS: Puromycin aminonucleoside nephrosis was induced by single intraperitoneal injection of puromycin aminonucleoside (PAN). Renal tissues were studied at 3, 7, 10 and 20 days after PAN injection by means of immunohistochemistry, RT-PCR, Western blotting and fluorescence. RESULTS: At day 3, CD2AP expression in podocytes began to decrease, and significantly decreased at day 7 and 10 (P
