The expression of B lymphocyte stimulator and its receptor BAFF-R in PBMCs from patients with SLE
- VernacularTitle:系统性红斑狼疮患者B淋巴细胞刺激因子及其受体BAFF-R的表达
- Author:
Dongsheng LI
;
Weizhen WANG
;
Chunyan SUN
;
Ming DAI
;
Linxue ZHU
;
Yiqun DUAN
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
B-Lymphocyte stimulatory factor;
Tumor necrosis factors
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the expression of B lymphocyte stimulator (BLyS) and its receptor BAFF-R(a receptor of B-cell activator factor, belonging to the TNF family) in peripheral blood mononuclear cells (PBMCs) from patients with systemic lupus erythematosus (SLE), and to explore their clinical significance. Methods The patients were separated into active group (n = 28) and inactive group (n = 24) according to the SLE disease activity index (SLEDAI). The mRNA and protein expression of BLyS and its receptor BAFF-R were measured by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western-blot in PBMCs from the patients and 21 healthy volunteers. The relationship between the expression of BLyS and BAFF-R and SLEDAI was analyzed. Results In the case of the expression of mRNA and protein of BLyS and BAFF-R, the patients had a higher level than the healthy controls (P 0.05). Conclusions These findings indicate that BLyS and its receptor BAFF-R might be involved in the pathogenesis of SLE. Also, BLyS expression level might be a new parameter for the evaluation of SLE disease activity and therapeutic effect.
