A study on relationship between the endothelial constitutive nitric oxide synthase gene polymorphism and the coronary disease in patients with type 2 diabetes
- VernacularTitle:内皮型一氧化氮合酶基因多态性与2型糖尿病并发冠心病的相关性研究
- Author:
Rong LUO
;
Jiyuan FAN
;
Peng ZHANG
;
Wei LIU
;
Zhihong GAO
;
Tiehong ZHU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Diabetes complications;
Coronary disease;
Nitric-oxide synthase;
Polymorphism,genetic
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the single nucleotide polymorphism in exon 7(G894T) or the insert/deletion polymorphism of variable number of tandem repeat in intron 4(4b/a) of the endothelial constitutive nitric oxide synthase(ecNOS) gene and the coronary disease in patients with type 2 diabetes.Methods In 80 patients with type 2 diabetes(group DM),92 type 2 diabetic patients with coronary disease(group DH) and 119 healthy controls(group NC),the polymorphism G894T was determined by polymerase chain reaction-restriction fragment length polymorphism analysis, while the polymorphism 4b/a was determined by polymerase chain reaction-variable number of tandem repeat analysis.Results The frequencies of allele T or genotype containing with allele T(GT or TT) in group DH were significantly higher than those in group DM or group NC(all P
