The relationship between PAI-1 activity and 4G/5G polymorphism in patients with type 2 diabetes from the coastal areas of Shandong province
- VernacularTitle:山东沿海地区2型糖尿病血浆纤溶酶原激活物抑制物-1活性与基因多态性的相关性研究
- Author:
Shuyan WANG
;
Xiaomei MENG
;
Yuxiao TANG
;
Xiao YU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Plasminogen activator inhibitor 1;
Polymorphism,genetic;
Triglycerides
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between plasminogen activator inhibitor-1(PAI-1) activity and PAI-1 promoter 4G/5G polymorphism in patients with type 2 diabetes from the coastal areas of Shandong province.Methods The 4G/5G allele polymorphism in the PAI1 gene promoter region were tested by allele specific PCR in 116 type 2 diabetes and 40 normal controls.The activity of plasma PAI-1 was assayed by chromogenic substrate method.Results The plasma PAI-1 activity in patients was higher than that in controls(P
