Study on the expression of nuclear factor-?B in nephridial tissue and the protective role of irbesartan on diabetic nephropathy in rats
- VernacularTitle:糖尿病大鼠肾组织中核因子-?B的表达及伊贝沙坦防护作用
- Author:
Xiaoli JING
;
Dongping WANG
;
Zhihong SONG
;
Jiong BI
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
NF-kappa B;
Angiotensin II type 1 receptor blockers
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevention and cure effects of irbesartan on diabetic nephropathy.Methods The tissues of kidneys were harvested for histomorphometry and transmission electron microscope observation.The nuclear factor-?B(NF-?B) activity was measured by electrophoretic mobility shift assays(EMSA) in renal tissue and the level of TNF-? was measured by radio-immunity in serum.Results The glomerular basement membrane thickening,the numbers of total glomerular cells and monocyt cells in a glomerulus in experimental group were less than those of the control group.The NF-?B activity and TNF-? level were positively correlated with glomerular basement membrane thickening.Conclusion The irbesartan can prevent and cure diabetic nephropathy by inhibiting NF-?B and depressing inflammatory response.
