Association of acute-phase proteins,interleukin-6,tumor necrosis factor-? with diabetic nephropathy in type 2 diabetes mellitus
- VernacularTitle:急性时相蛋白和IL-6及TNF-?与2型糖尿病肾病的关系
- Author:
Chaoming WU
;
Youjin PAN
;
Li NI
;
Xiangtong ZHAO
;
Chao ZHENG
;
Xiaoying WU
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Acute-phase proteins;
Interleukin-6;
Tumor necrosis factor-alpha
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the levels of serum acute-phase proteins,interleukin-6(IL-6) and tumor necrosis factor-?(TNF-?) in different stages of diabetic nephropathy in type 2 diabetes mellitus(T2DM) and to explore the clinical significance.Methods One hundred and five patients with T2DM diagnosed by WHO(1999) criteria were divided into three subgroups according to their urinary albumin excretion rate(UAER): 34 cases normal UAER group(NA group),31 cases microalbuminuria group(MA group) and 30 cases clinical proteinuria group(CA group).Thirty-three healthy individuals were selected as controls(NC group).The levels of acute-phase proteins including C reactive protein(CRP),?_1-acid glycoprotein(?_1-AAG),ceruloplasmin(CER) and haptoglobin(THP) were measured with immunoscattering assay,The levels of IL-6 and TNF-? were detected with electrochemiluminescence immunoassay.Results The levels of serum acute-phase proteins,IL-6,TNF-? were significantly higher in patients with T2DM than those in NC group(all P
