Administering a second rinse solution of low-potassium-dextran before reperfusion ameliorates the donor lung
- VernacularTitle:移植前低钾右旋糖苷液二次灌洗减轻供肺再灌注损伤
- Author:
Pingshan WANG
;
Qingyu WU
;
Bin GUAN
;
Shiyong SHI
- Publication Type:Journal Article
- Keywords:
Lung transplantation;
Reperfusion injury;
Dextrans;
Irrigation
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To studied the effects of administering a second rinse solution of low-potassium-dextran(LPD) before reperfusion on the donor lung of rat after long time,cold ischemic preservation.Methods Twenty-four rats were randomly divided into control group(n=12) and trial group(n=12).Donor lungs of control group were flushed with LPD solution.The levels of malonaldehyde(MDA),myeloperoxidase(MPO) and interleukin-8(IL-8) were tested in the tissue of right lung and the left lungs were reperfused with venous blood for 30 minutes.The partial pressure of oxygen(PaO_2),PaP and PawP were measured at every 10 minutes intervals during reperfusion.After reperfusion,the MDA,MPO activity and interlukin-8(IL-8) were determined in the lung tissue.Results The levels of MDA,MPO and IL-8 decreased significantly in right lung of trial group than those in control group(P
