The expression of an alternative spliced variant of human interleukin-4 in patients with atopic asthma
- VernacularTitle:白细胞介素4剪接变异体在哮喘患者中的表达
- Author:
Xinyu TI
;
Haowen QI
;
Wei HAN
;
Shujun LI
;
Changgui WU
;
Yingqi ZHANG
- Publication Type:Journal Article
- Keywords:
Asthma;
Interleukin-4
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions and effects of interleukin-4(IL-4) and its alternative spliced variant(IL-4?2) in patients with atopic asthma.Methods The expressions of IL-4 and IL-4?2 were detected in 10 cases of patients with atopic asthma using a quantitative nested reverse-transcription polymerase chain reaction(RT-PCR) protocol.Result The expression level of IL-4 was higher in the patients with atopic asthma than that of the healthy controls.The median ratio of IL-4 to IL-4?2 was much higher in the patients with atopic asthma compared with that of the healthy controls.Conclusion The relative expression of IL-4 and IL-4?2 may play an important role in the mechanism of the pulmonary pathology in patients with atopic asthma,and may be one of the reason for the functional diversity of Th2 cells in different clinical conditions.
