Expression of matrix metalloproteinase 1 and tissue inhibitor of metalloproteinase 1 in biopsy liver from patients with fibrosing cholestatic hepatitis
- VernacularTitle:纤维化淤胆性肝炎肝组织基质金属蛋白酶1及金属蛋白酶组织抑制因子1的表达
- Author:
Xingfeng RENG
;
Xiaokun WANG
;
Ying TANG
;
Qun YANG
;
Jingan LI
;
Jing YU
;
Ya GE
;
Ligong TANG
- Publication Type:Journal Article
- Keywords:
Hepatitis,autoimmune;
Hepatitis B virus;
Liver;
Interstitial collagenase;
Tissue inhibitor of metalloproteinase-1;
Collagen
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the fibrosis mechanism of patients with fibrosing cholestatic hepatitis(FCH) in the way of degradation of collagen.Methods The expressions of matrix metalloproteinase 1(MMP1) and tissue inhibitor of metalloproteinase 1(TIMP1),and contents of type I,III collagen proteins were detected by immunohistochemical staining in the liver tissues of 9 cases with FCH associated with HBV developed following renal transplantation and 5 cases without liver disease as controls.Results The expressions of MMP1 and TIMP1,and type I,III collagen proteins in the patients with FCH were significantly higher than those in the control group.There was a positive correlation between the expressions of type I,III collagen proteins and TIMP1/ MMP1 ratio.Conclusion Hepatic fibrosis in the patients with FCH associated with HBV developed following renal transplantation may be relative to the increase of TIMP1 expression which inhibit the degradation of collagen.
