Significance of combination of serum anti-nucleosome and anti-dsDNA antibodies in patients with systemic lupus erythematosus
- VernacularTitle:联合检测抗核小体抗体和抗dsDNA抗体对SLE疾病活动和脏器损害的意义
- Author:
Guosheng WANG
;
Hong ZHANG
;
Shuguang SHAN
;
Guojun YANG
;
Long QIAN
;
Wei WANG
;
Xiaomei LI
;
Xiangpei LI
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Antibodies,antinuclear;
Nucleosomes;
DNA
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of antinucleosome and anti-dsDNA antibodies on the disease flare and organ damage in patients with systemic lupus erythematosus(SLE).Methods Sixty-nine SLE patients were divided into disease flare group,stable group,lupus nephritis group and non-lupus nephritis group.Serum levels of anti-nucleosome antibody and anti-dsDNA antibody were measured with enzyme linked immunosorbent assay(ELISA) and indirect immunofluorescence(IIF),respectively.Results The positive rates of serum anti-nucleosome and anti-dsDNA antibodies were 55.10% and 47.82% respectively and the rates were significantly higher in disease flare group than those in disease stable group(P
