The effects of leptin and interleukin-6 on the bone metabolism in the post-menopause women
- VernacularTitle:瘦素和白介素-6在绝经后妇女骨代谢中的作用
- Author:
Gelan LU
;
Bin ZHAO
;
Weidong ZHANG
;
Hongfan JIANG
- Publication Type:Journal Article
- Keywords:
Osteoporosis,postmenopausal;
Interleukin-6;
Leptin
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathogenesy of postmenopausal osteoporosis and the influence of leptin on osteoporosis.Methods Healthy woman volunteers with different ages were divided into four groups: 25～34 years old(n=37),35～44 years old(n=31),45～54 years old(n=30),postmenopausal women 55～65 years old(n=40),with no significant difference in BMI among each groups.The serum levels of leptin,follicle-stimulating hormone(FSH),luteinizing,hormone(LH),beta-estradiol(E_2),testosterong(T),boneglaprotein(BGP),alkaline phosphates(ALP),tatrate-resistantacid phosphatase(TRAP),interleukin-6(IL-6),plasma calcium(Ca) and phosphate(P) were detected.Results The serum levels of leptin and BGP increased with the age in the nonobese women group.The serum levels of FSH,IL-6 and TRAP increased while those of E_2 and BMD decreased in the postmenopausal women compared with other groups.Conclusion Leptin serves as an important factor in promoting bone formation during bone rebuilding of postmenopausal women.The serum levels of leptin and BGP increase and bone formation increases.The E_2 and leptin contribute to the enhancement of bone formation and bone absorption in the postmenopausal women.The level of E_2 decreases but it acts more efficiently than leptin.The bone absorption is faster than bone formation,which contributes to the pathopoiesis of osteoporosis in postmenopausal women.
