Study on the roles of autoantibodies against ?1 adrenoceptor and M2 cholinergic receptor in patients with chronic renal insufficiency
- VernacularTitle:慢性肾功能不全患者血清抗?1肾上腺素受体和M2胆碱能受体自身抗体的研究
- Author:
Linshuang ZHAO
;
Yuhua LIAO
;
Min WANG
;
Zihua ZHOU
;
Guangda XIANG
;
Jie HOU
;
Ling LE
;
Lin XU
- Publication Type:Journal Article
- Keywords:
Kidney failure,chronic;
Receptors,adrenergic,beta 1;
Receptors,cholinergic
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the roles of autoantibodies against ?1 adrenoceptor(?1-receptor)and M2 cholinergic receptor(M2-receptor)in patients with chronic renal insufficiency.Methods The epitopes of the second extracellular loop of ?1 receptor and M2 receptor were synthesized and used respectively to detect the sera autoantibodies against ?1 receptor and M2 receptor by enzyme linked immunosorbent assay(ELISA) in 76 patients with chronic renal insufficiency,60 cases with hypertension and 40 healthy controls.Results In patients with chronic renal insufficiency,the positive rates of the autoantibodies against ?1-receptor and M2-receptor were 56.7% and 38.1% respectively,which were much higher than those of patients with hypertension(18.3% and 11.7%) and higher than those of healthy controls(17.5% and 15.0%)(all P
