Link of type 2 diabetes with insulin resistance and cytokines
- VernacularTitle:细胞因子与2型糖尿病及胰岛素抵抗的相关性研究
- Author:
Yong ZHOU
;
Jian ZHU
;
Yi WANG
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Insulin resistance;
Cytokine
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study on the changes of the IL-6、IL-8、TNF-? in the type 2 diabetes with insulin resistance and the relation of plasma glucose or insulin resistance and cytokines. Methods (1) To assay the serum level of cytokines in 90 cases with type 2 diabetes mellitus (T2DM) and 30 normal controls. (2)To measure the level of fasting plasma glucose (FPG),hemoglohin A_1c (HBA_1c),fasting insulin(FINS),fasting C-peptide (FCP).(3) To analysis the relation of the level of FPG,HBA_1c,FINS,FCP and cytokines. Results (1) The serum levels of cytokines in T2DM group were significantly increase than in control groups,IL-6 and TNF-? in T2DM group with insulin resistance were significantly increase than in T2DM group without insulin resistance (2) There was significantly positively correlated between insulin resistance and the increasing of cytokine levels. Conclusion There is an excess activation of cytokines in T2DM,which is significantly correlated with insulin resistance. Cytokines play the important role in the occurrence and development of T2DM and insulin resistance.
