Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase.
10.3350/cmh.2015.21.4.319
- Author:
Yasuko IWAKIRI
1
Author Information
1. Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA. yasuko.iwakiri@yale.edu
- Publication Type:Research Support, N.I.H., Extramural ; Review
- Keywords:
iNOS;
NO;
Liver sinusoidal endothelial cell;
Hepatic stellate cell;
Kupffer cell
- MeSH:
Endothelial Cells/metabolism;
Hepatic Stellate Cells/metabolism;
Humans;
Kupffer Cells/metabolism;
Liver Cirrhosis/metabolism/*pathology;
Nitric Oxide/*metabolism;
Nitric Oxide Synthase Type II/antagonists & inhibitors/genetics/*metabolism;
Polymorphism, Single Nucleotide;
RNA, Untranslated/metabolism
- From:Clinical and Molecular Hepatology
2015;21(4):319-325
- CountryRepublic of Korea
- Language:English
-
Abstract:
The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focusing on 1) iNOS biology, 2) iNOS-expressing liver cells, 3) iNOS-related therapeutic strategies, and 4) future directions.
