The Significant and Concentration Changes of Endothelin in Brain After Cerebral Ischemia Pretreatment in the Rats
- VernacularTitle:大鼠脑缺血预处理后脑组织内皮素含量的改变及其意义
- Author:
Jianrong MA
;
Nianjun REN
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia pretreatment;
Ischemia tolerance;
Endothelin
- From:
Journal of Chinese Physician
2002;0(S1):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the concentration changes of endothelin-1(ET-1) in brain after cerebral ischemia pretreatment in the rats and the relationship of ET-1 and ischemia tolerance. Methods Cerebral ischemia pretreatment was performed by ameliorated obstructing four blood vessels in wistar rats. The concentrations of ET-1 in brain were measured by radioimmunoassay(RIA). Results The concentrations of ET-1 in brain in the expreimental groups of 12 hour and 24 hour were higher than that of non-pretreatment( P
