Resveratrol Protects Against Gentamicin Ototoxicity
- VernacularTitle:白藜芦醇拮抗庆大霉素耳毒性的实验研究
- Author:
Shuyun GUO
;
Weiguo HUANG
;
Xiaoli SUN
- Publication Type:Journal Article
- Keywords:
Gentamicins;
Ototoxicity;
Resveratrol;
Drug interactions
- From:
Journal of Audiology and Speech Pathology
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the prevention of gentamicin ototoxicity by resveratrol(Res) in guinea pigs.Methods Auditory brainstem response and cochlear preparation transmission electron microscope were used to evaluate the effects of hair cell on hearing threshold and morphology of hair cell. Serum levels of GM were also tested. It was comprised of five groups,each group had eight animals.GM and Res were tested alone and in combination,besides control group.Results GM group developed a progressive threshold shift. Injury in high frequency was significantly more severe than that in low frequency (P
