Expression of Inducible Nitric Oxide Synthase in the Cochlear Stria Vascularis of Guinea Pig Damaged By Streptomycin
- VernacularTitle:iNOS在链霉素耳中毒豚鼠耳蜗血管纹的表达
- Author:
Lijuan SHI
;
Jie GUAN
;
Hao TANG
- Publication Type:Journal Article
- Keywords:
Inducible nitric oxide synthase;
Streptomycin;
Cochlea stria vascularis
- From:
Journal of Audiology and Speech Pathology
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of inducible nitric oxide synthase(iNOS) in the cochlear stria vascularis(SV) of guinea pigs after streptomycin(SM).Methods Auditory brainstem response(ABR) was used as measurement index,and combining with transmission electron microscope(TEM),immunohistochemical staining and image quantitative analysis technique, to detect iNOS expression in the cochlea stria vascularis of guinea pigs and the change of morphology after SM.Results 10 days after adminitration, ABR threshold of SM group increased more significantly than that of the control group(P
