Inhibitory effect of vitamin E succinate on experimental breast cancer in nude mice
- VernacularTitle:维生素E琥珀酸酯对乳腺癌荷瘤裸鼠的抑瘤作用
- Author:
Wei ZHANG
;
Junchu ZHANG
;
Xinyun XU
;
Daqiao ZHU
;
Jin HE
;
Qiang WANG
- Publication Type:Journal Article
- Keywords:
Succinic Anhydrides/pathol;
Brease Neoplasms/drug ther;
MCF-7
- From:
Chinese Journal of General Surgery
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the inhibitory effect of vitamin E succinate(VES) on experimental breast cancer in nude mice.Methods MCF-7 human breast cancer cells were inoculated subcutaneously in nude mice.VES was administrated at a dosage of 150mg/kg body weight for 5 weeks.Then,the size of the tumor was measured and cell cycle and cell surface Fas/FasL were detected by flow cytometry.Fas/FasL expression in tumor tissue was detected with immunohistochemistry,and apoptosis index was detected by TUNEL method.Results VES showed obviously inhibitory effect on the growth of graft breast cancer tumor in vivo.VES treatment blocked tumor cells in G_0/G_1 phase.Fas/FasL expression was up-regulated accompanied with a rise of apoptotic index in tumor tissue.Conclusions VES had potent inhibitory effect on MCF-7 breast cancer graft in nude mice.The mechanism involved may be related to the up-regulation of Fas/FasL expression and promotion of apoptosis of tumor cells.
