The Protective Effect of Guishu Blood-activating Capsules on Cerebral Ischemical Reperfusion Injury Model Rats
- VernacularTitle:归术活血胶囊对脑缺血再灌注损伤模型大鼠的保护作用
- Author:
Shengchun WANG
;
Jianfeng LI
;
Mingyi LIU
;
Zengfa CAO
- Publication Type:Journal Article
- Keywords:
Guishu blood-activating capsule;
Focal cerebral ischemia reperfusion;
Brain edema;
Aspartate aminotrans?ferase;
Glutamate aminopherase;
Malonaldehyde;
Lactate dehydrogenase
- From:
China Pharmacy
2005;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the protective effect of Guishu blood-activating capsule on cerebral ischemical reperfusion injury of rats.METHODS:The cerebral embolism model rats were established,the rats were randomly divided into model group,nimodipine positive control group,Guishu blood-activating capsule(high,medium and low dosage groups,re?spectively)group and with another sham operation group established.Each group was administered intragastrically with water or the corresponding drugs,the cortexes and hippocampus tissues of the rats were divided into the injured side and the control side,the contents of aspartate(Asp),glutamate(Glu),malonaldehyde(MDA),lactate dehydrogenase(LD),the tumor necrosis factor?(TNF-?)and the activity of glutathione peroxidase(GSH-Px)were determined,the cerebral infarct size was determined by red tetrazoline staining method and the cerebral water content was determined by oven dry process.RE?SULTS:Compared with the model group,in one or several sub-groups of Guishu group,no marked change was noted in the content of Asp while that of the Glu in the injured side of the hippocampus tissues decreased significantly(P
