The relationship between consciousness, memory and event-related potentials during propofol sedation and anesthesia
- VernacularTitle:不同镇静程度下健康志愿者事件相关电位与意识和记忆的关系
- Author:
Di WU
;
Yun YUE
;
Zhipeng XU
- Publication Type:Journal Article
- Keywords:
Event-related potentials, P300;
Consciousness;
Memory;
Conscious sedation
- From:
Chinese Journal of Anesthesiology
1995;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the changes in event-related potentials (ERPs) and examine the relationship between memory, consciousness and ERPs during propofol sedation and anesthesia. Methods Ten young healthy volunteers were enrolled in this study. Baseline values of ERPs, noninvasive BP (NBP), ECG and SpO2 were recorded before induction of sedation and anesthesia. The level of sedation was assessed using OAA/S scale. Sedation and anesthesia were induced and maintained with target-controlled infusion (TCI) of propofol. The amplitude, peak value and latency of the potential N1 and P3, NBP ECG and SpO2 were recorded at each level of sedation and anesthesia. A list of words was played via headphone at OAA/S score of 3 or 2. Memory test was performed 4hr after the recovery from anesthesia. Target and distractor hits in inclusion and exclusion test were obtained and explicit and implicit memory scores were calculated. Results (1) At OAA/S score of 3 the amplitude of N1 was attenuated and that of P3 suppressed ( P
