The expressions and clincal significance of PTEN and pAkt in hepatocellular carcinoma
- VernacularTitle:抑癌基因PTEN与pAkt在肝细胞肝癌中表达及其意义
- Author:
Enyu LIU
;
Jilin YI
;
Wei SONG
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocyte;
Phosphatase and tensin homlog deleted on chromosome ten protein;
Protein kinase B/Akt;
Neoplasm invasion
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions and clinical significance of the tumor supressor gene phosphatase and tensin homlog deleted on chromosome ten protein(PTEN) and oncogene phosphoserine/threonine protein kinase B(phospho-serine/threonine protein kinase Akt/PKB,pAkt) in hepatocellular carcinoma(HCC).Method The expressions of PTEN and pAkt in 65 cases of HCC and their pericarcinomatous tissues were detected by immunohistochemical staining with S-P method.Results The positive expression rate of PTEN in HCC was significantly lower than that in pericarcinomatous liver tissues,and the positive rate of pAkt was significantly higher than that in pericarcinomatous liver tissues(all P
