The changes of endogenous interleukin-10,NOS and iNOS during myocardial ischemia and reperfusion in rats
- VernacularTitle:大鼠心肌缺血再灌注IL-10、NOS、iNOS的变化
- Author:
Xiling SHENG
;
Dongming WANG
;
Chang CHEN
- Publication Type:Journal Article
- Keywords:
Ischemia/reperfusion;
Interleukin-10;
Nitric oxide synthase;
Inducible nitric oxide synthase;
Methylprednisolone
- From:
Journal of Chinese Physician
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and relationships between the serum endogenously produced interleukin-10(IL-10),nitric oxide synthase(NOS) and inducible nitric oxide synthase(iNOS) in acute myocardial ischemia and reperfusion.Methods Forty-two rats were randomly divided into two groups: myocardial ischemia and reperfusion group(the control group) and methylprednisolone treatment group.The rats in the control group and methylprednisolone treatment group received intravenous injection of placebo and methylprednisolone before ischemia respectively.The plasma IL-10,NOS and iNOS were detected at 0.5 h after ischaemia and 0.5h,2 h after reperfusion,respectively.Result The plasma IL-10,NOS and iNOS gradually increased at 0.5 h after ischaemia and 0.5h,2 h after reperfusion in the two groups.The levels of plasma IL-10 were significantly higher in the methylprednisolone treatment group in different time points than those in the control(all P
