Prognostic value of cyclin D1 and CDK6 expression in patients with gastric carcinoma
- VernacularTitle:胃癌组织中细胞周期蛋白D1和细胞周期蛋白质依赖激酶6的表达与预后的关系
- Author:
Kewei JIANG
;
Shan WANG
;
Yingjiang YE
;
Youzhi YU
;
Ruyu DU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Cyclin D1;
Cyclin-dependent kinases
- From:
Chinese Journal of General Surgery
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the role of a cell cycle regulator, cyclin D1 and CDK6 in patients with gastric carcinoma. Method Tissue samples from 48 patients with gastric carcinoma were included in the current study. Expression levels of cyclin Dl and CDK6 in samples of normal mucosa and tumor tissue were analyzed by Western blot. Result Overexpression of cyclin Dl and CDK6 protein were demonstrated in 58% and 69% of gastric cancer tissues, respectively. Several clinicopathologic parameters, including depth of tumor invasion, pathologic lymph node status and tumor stage ( P
