Effects of Aminoguanidine and Vitamin C on Serum Laminin of Rats with Diabetic Nephropathy Model
- VernacularTitle:氨基胍和维生素C对糖尿病肾病模型大鼠血清层粘连蛋白的影响
- Author:
Qiangxiang LI
;
Wei LI
;
Xiaoying XIE
;
Yushu WU
;
Li ZHOU
;
Ling GUO
- Publication Type:Journal Article
- Keywords:
Aminoguanidine;
Vitamin C;
Diabetic nephropathy model;
Laminin
- From:
China Pharmacy
2005;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the effects of aminoguanidine and vitamin C on serum laminin of rats with diabetic nephropathy model. METHODS: The rats were randomly divided into normal control group, diabetes model group, vitamin C group,aminoguanidine group,vitamin C plus aminogucinidine group. The diabetes model(Type 1) was established in all groups except the normal control group by injecting them intraperitoneally with streptozotocin, after which, they were treated with the corresponding drugs for 16 weeks. During and after the treatment, the general state, blood gloucose levels, glycosylated hemoglobin, serum laminin, urea nitrogen, serum creatinine, and the 24-hours urinary albumin excretion rate of each group were observed and determined. RESULTS: The serum laminin levels increased and diabetic nephropathy occurred in all the 4 groups after being modelled. Aminoguanidine group, vitamin C had no effect on blood glucose level, while they could improve the basic condition and the combination of the two could significantly decrease serum levels of laminin, urea nitrogen, creatinine and the 24-hours urinary albumin excretion rate. CONCLUSION: Aminogucinidine and vitamin C couldn't decrease the blood sugar level but the combination of which has a synergistic action to decrease serum laminin level while preventing renal function.
