Therapeutic Window Concentration of Tacrolimus: Survey of 56 Cases of Renal Transplant Recipients
- VernacularTitle:56例患者肾移植术后他克莫司治疗窗浓度范围再探讨
- Author:
Shouchun WANG
;
Kaiying SI
;
Jie LUAN
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Tacrolimus;
Therapeutic window concentration
- From:
China Pharmacy
2005;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To explore the therapeutic window concentration of tacrolimus(FK506) suitable for Chinese renal transplant recipients. METHODS: The whole blood valley concentration level in 56 renal transplant recipients 12h after oral administration with FK506 was determined by MEIA (Microparticle Enzyme Immunization). The rejections and the renal toxic reaction were observed as well. RESULTS: The recommended therapeutic window concentration of FK506 for Chinese renal transplant recipients were the following: 9～14?g/L during the first month; 8～12?g/L during the second to the third month; 6～10?g/L during the fourth to the sixth month; 4～6?g/L during the seventh to the twelfth month. CONCLUSION: FK506 has a satisfactory immune suppression effect while reducing incidences of rejections and renal toxic reactions if used within the above therapeutic window concentration.
