Peripheral Blood Lymphocytes Apoptosis and Expression of Fas and Bcl-2 in Patients with Secondary Syphilis
- VernacularTitle:二期梅毒患者外周血淋巴细胞凋亡及其Fas、Bcl-2表达的研究
- Author:
Wenjun ZENG
;
Yiming FAN
;
Zhihua WU
- Publication Type:Journal Article
- Keywords:
Syphilis;
Lymphocyte subsets;
Apoptosis;
Antigens,CD95;
Proto-oncogene proteins c-bcl-2
- From:
Chinese Journal of Dermatology
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between apoptosis of peripheral blood lymphocytes (PBLCs) and impaired immunity by assessing the apoptosis and expression of Fas and Bcl-2 in PBLCs of patients with secondary syphilis. Methods Flow cytometry (FCM) was used to detect PBLC apoptosis as well as Fas and Bcl-2 expression in 33 patients with secondary syphilis and 30 normal controls. Results The Fas expression on PBLCs and CD4+ cells was significantly higher in patients than that in controls (P 0.05). The apoptosis levels were significantly higher in PBLCs and CD4+ cells in patients than those in controls (P 0.05). In patients group, the apoptosis levels of both PBLCs and CD4+ cells had a positive correlation with the Fas expression (r = 0.68, P
