Factors Affecting on Treatment of Hyponatremia in Hyponatremic Patients.
- Author:
Seok Woo KANG
1
;
Seong Kyu YANG
;
Jun Ho RYU
;
Sang Woong HAN
;
Kyung Hwan MIN
;
Ho Jung KIM
Author Information
1. Department of Internal Medicine, Han Yang University Kuri Hospital, Kuri, Korea.
- Publication Type:Original Article
- Keywords:
Hyponatremia;
Affecting factor on treatment of hyponatremia
- MeSH:
Clinical Medicine;
Diagnosis;
Diuretics;
Humans;
Hypokalemia;
Hyponatremia*;
Potassium;
Prognosis;
Retrospective Studies;
Sodium
- From:Korean Journal of Nephrology
2000;19(3):421-428
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hyponatremia, well known as a serious medical condition, is the most frequent electrolyte disorder in clinical medicine. The aim of this study is to bring to readers affecting factors in hyponatremia treatment and to suggest effective treatment guideline. We studied general characteristics, associated serum potassium change, relationship of sodium concentration in urine, and affecting factors on serum sodium correction in 76 hyponatremic patients who had admitted Hanyang University Kuri Hospital. These 73 hyponatremic patients were divided into 10 groups according to cause and treatment by retrospective analysis(1 group : G-I origin, 2 group : CRF, 3 group : CHF, 4 group: LC, 5 group : adrenal origin, 6 group : diuretics use, 7 group : CHF with di- uretics use, 8 group : LC with diuretics use, 9 group : polydypsia, 10 group : SIADH). Serum sodium were 124.2+/-6.9mEq/L in initial diagnosis, 125.6 +/-7.7mEq/L after 48 hour, and 129.8+/-6.3mEq/L in final evaluation. Among these hyponatremic patients, thirty patients' (41.1%) sodium correction rate were below 0.5mEq/L/hr during initial 48 hour and fifteen patients(20.5%) were corrected above 135mEq/l in serum sodium Initial serum potassium was average 4,07mEq/L, and 15 patients in 73 hyponatremic patients were hypokalemic feature. Eight patients of 15 hypokalemic patients were corrected to normal potassium level and in addition, four patients of 8 corrected patients were corrected to normal sodium level above 135mEq/L. The disease frequency were highest in GI origin (31.5%), followed by SIADH(20.5%) and LC(12.3%). In our study, hyponatremia correction was not related to patient sex, age, and initial serum sodium concentration. In conclusion, Hyponatremia prognosis was not related to initial serum sodium concentration and corection rate, but related to treatment of underlying disease. And hypokalemia acompanied by hyponetremia was corrected after correction of hyponatremia.
